Study: With stall dust substances against allergies

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Avoid allergies with materials from stall dust

It has long been known that children growing up on farms are less likely to suffer from allergies. Now doctors are trying to find out how substances from the house dust could be used to prevent allergies in the future.

Like a kind of vaccination Up until yesterday, March 7th in Mainz, doctors from several countries discussed in Mainz how substances from stable dust could be used in the future to prevent allergies. It has long been known that children growing up on farms are less likely to suffer from allergies. Professor Joachim Saloga from the Johannes Gutenberg University Mainz said on the sidelines of the 26th Mainz Allergy Workshop: "Research is currently underway on how to shape the immune system of small children in such a way that fewer allergies develop." He added: " It would be like some kind of vaccination. But that is not yet on the market, these are basic considerations. "

Hay fever risk of farm children only half as big As early as 2011, scientists at the Ruhr University Bochum had discovered a sugar molecule in the dust, which "may protect against allergies and allergic asthma". According to the researchers, the so-called arabinogalactan occurs in fodder plants "in large quantities and prevents the immune system from overreaching defense reactions if it is inhaled in high concentration in the first year of life". The scientists now want to investigate whether arabinogalactan can be used for prophylaxis or therapy. The Marburg allergist Harald Renz and his team discovered over ten years ago why farm children are less likely to develop allergies. Your risk of asthma or hay fever is only half as high as that of children growing up in urban areas. The scientists came to the conclusion that this was due to the microbes that are found in large numbers on farms. These would turn off the genes that set off allergic reactions.

Tailoring therapies more to the patient At the workshop in Mainz, the doctors also discussed how inflammatory symptoms can be combated. For example, there is new knowledge about how the inflammatory reaction works in allergic diseases. "This in turn makes it possible to develop new targets for therapies to inhibit precisely these processes," says Saloga. Even if it has been known for a long time which cells play a role in this, there are "always new insights into which substances they produce and which receptors they act on," says the Mainz doctor. At the same time, it is about tailoring therapies even more to the patient. “We used to talk about house dust allergy,” said Saloga, “but there were a lot of different allergens in the house dust. The house dust mite, for example, but also cockroach allergens. ”It helps for therapy if it is clarified which individual molecules triggered the allergic reactions.

A third of all adults have already had an allergy In Germany, almost a third of adults have suffered from an allergy in their lifetime. This was the result of a study by the Robert Koch Institute (RKI) last year. Against the background of the fact that allergies have developed into a "widespread disease", the RKI carried out an investigation into the "frequency of allergic diseases in Germany". At least 20 percent would have had at least one allergy at the time of the announcement. Those affected have allergies to plant pollen, mites, animal hair, insect venom or foods such as nuts or eggs and dairy products, but the majority of allergy sufferers (14.8 percent) are affected by hay fever. It was also shown that women were generally affected more often than men and younger people more often than older people. An itchy rash and pustules, watery eyes or a runny nose, and shortness of breath are just a few symptoms that may indicate an allergy. Even if, in the worst case, anaphylactic shock can occur, which can lead to circulatory shock and organ failure, allergies are far less pronounced in most people. By not only influencing social life but also reducing performance and work capacity, allergies can severely reduce the overall quality of life. (ad)

Image: Bettina Stolze /

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