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Asthma conference in Hanover: polyps in the nose: triggers for asthma?
Nasal polyps are partly responsible for the fact that patients suffer from bronchial asthma. Because the polyps are carriers of bacteria to which the body reacts with a strong production of "immunoglobulin E" (IgE). Immunoglobulin E are antibodies that are primarily intended to ward off parasites. However, you are also responsible for allergies.
According to new knowledge, many asthma diseases, some of which are severe, are a result of polyps in the nose. This was reported by Prof. Claus Bachert, Chairman of the German Society for Allergology and Clinical Immunology (DGAKI), at the German Allergy Congress in Hanover, Lower Saxony, which opened today. According to the latest studies, polyps with the bacterial strain “staphylococci” were found in about eight out of ten asthma patients. Staphylococci are gram-positive so-called spherical bacteria that are stored in irregular piles. They occur primarily on the skin and in human mucous membranes. There are numerous subspecies and forms of these bacterial strains. In many affected people, the human organism reacts with a strong production of immunoglobulin E (IgE). This happens in around 40 percent of cases.
For medical professionals, immunoglobulin E is a typical allergy antibody. "It is the substance that arms the immunologically active mast cells and causes allergic symptoms when in contact with allergens," explained Professor Claus Bachert at the allergy conference in Hanover.
Immunoglobulin E is directed against a variety of different allergens. However, patients with polyps often do not get allergy but asthma. But there is hope, as Claus Bachert reports. Because studies have shown that antibodies against the IgE already exist. The professor said: "We can successfully treat them with an already available monoclonal antibody against IgE. This has been found in a placebo-controlled study."
In the study, it was observed that the polyps and asthma symptoms could be suppressed by the administration of the monoclonal antibodies. There was a "significant decrease in polyps and asthma symptoms". At the conference, Bachert emphasized that the study had discovered a new clinical picture that was previously completely unknown. A large number of asthma patients can now hope for new treatment approaches. (sb, 09/11/2010)
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