Antipyretic pain relievers reduce antibodies

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Antipyretic pain reliever

Antipyretic pain relievers can reduce the formation of antibodies in humans. Lung doctors of the German Lung Foundation (DLS) in Hanover: Over-the-counter pain relievers could have a negative impact on our immune system and reduce the effect of vaccinations

With some vaccinations, such as pneumococci, diptheria, tetanus and whooping cough, according to current statements by scientists, it can be observed that agents from the group of so-called non-steroidal anti-inflammatory drugs (NSAIDs) reduce the immune response of our organism.

In a study funded by the British pharmaceutical company GlaxoSmithKline, researchers led by a professor from the Faculty of Military Health Science at the University of Defense in Hradec Králové, Czech Republic, observed the effect of prophylactic paracetamol doses in children aged 9 to 16 weeks. The study was published in mid-October 2009 in the medical journal “The Lancet”, which has been published since 1823 and which is now published by Elsevier Verlag.

In their study, they participated in a total of 459 small children from 10 centers in the Czech Republic who had received vaccinations against various infectious diseases. 226 of the children received the prophylactic drug paracetamol 24 hours before the respective vaccination. The other group of 233 children did not receive any. Professor Rymula and colleagues found that the group of children who received paracetamol got less fever, but also that the antibody production against multiple vaccinations was significantly reduced. Agents like paracetamol belong to the so-called "non-steroidal anti-inflammatory drugs (NSAID)". Part of their effect is that after ingestion they block an enzyme (Cox-2) in our organism.

Board member of the German Lung Foundation (DLS): "Effect of vaccination reduced"
Prof. Dr. med. Adrian Gillissen, board member of the German Lung Foundation (DLS), director of the Robert Koch Clinic in Leipzig and specialist in internal medicine, explained on the DLS website:

"In the context of a vaccination, however, this is counterproductive, since Cox-2 is necessary for the optimal production of antibodies (B lymphocytes)," explains Gillissen. “Not only paracetamol, but all drugs belonging to the NSAID group are suspected of impairing the ability of B-lymphocytes to produce antibodies and thus reducing the desired effect of a vaccination - that is, the formation of antibodies against components of the vaccine . "

The Czech scientists therefore come to the conclusion in their study that the administration of antipyretic painkillers before vaccinations is not advisable.

Vaccinations in childhood are not only viewed very critically in naturopathy. But one can only hope that in vaccine-affirming circles, especially among pediatricians and parents, these findings will be used as a criterion in the timing of the vaccination. (Thorsten Fischer, naturopath osteopathy December 24th, 2009)

Pulmonologist on the net article

Study of Czech scientists in "The Lancet"

The Clinical Trials Studies

Author and source information

Video: How Do Pain Relievers Work? - George Zaidan


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